.isoform-page[data-astro-cid-t7yhajqz]{background:var(--color-canvas);container-type:inline-size}.page-shell[data-astro-cid-t7yhajqz]{width:100%;max-width:80rem;padding-inline:var(--page-gutter);margin:0 auto}.eyebrow[data-astro-cid-t7yhajqz]{margin:0 0 var(--space-3);color:var(--color-brand-strong);font-size:var(--font-size-xs);font-weight:var(--font-weight-semibold);letter-spacing:.16em;text-transform:uppercase;padding:0}.intro-section[data-astro-cid-t7yhajqz]{grid-template-columns:minmax(0,1.2fr) minmax(18rem,.8fr);align-items:start;gap:clamp(2rem,7vw,7rem);padding:clamp(2rem,4vw,3.5rem) 0;display:grid}.intro-section[data-astro-cid-t7yhajqz] h2[data-astro-cid-t7yhajqz]{max-width:14ch;color:var(--phaeno-rna-900);font-size:clamp(2.7rem,5.5vw,5.3rem);font-weight:var(--font-weight-medium);letter-spacing:-.055em;margin:0;padding:0;line-height:.96}.intro-section[data-astro-cid-t7yhajqz] h2[data-astro-cid-t7yhajqz] span[data-astro-cid-t7yhajqz]{color:var(--color-brand)}.intro-section__copy[data-astro-cid-t7yhajqz]{padding-top:var(--space-5);padding-bottom:.35rem}.intro-section__copy[data-astro-cid-t7yhajqz] p[data-astro-cid-t7yhajqz]{color:var(--phaeno-neutral-700);font-size:var(--font-size-lg);margin:0;padding:0;line-height:1.65}.intro-section__copy[data-astro-cid-t7yhajqz] .lead[data-astro-cid-t7yhajqz]{margin-bottom:var(--space-5);color:var(--phaeno-rna-900);font-size:clamp(1.25rem,2vw,1.6rem);font-weight:var(--font-weight-medium);line-height:1.45}.resolution-section[data-astro-cid-t7yhajqz]{border-radius:var(--radius-2xl);background:var(--phaeno-neutral-100);padding:clamp(2.5rem,4.5vw,4.25rem)}.section-heading[data-astro-cid-t7yhajqz]{max-width:49rem;margin-bottom:clamp(1.75rem,3.5vw,2.75rem)}.section-heading[data-astro-cid-t7yhajqz] h2[data-astro-cid-t7yhajqz],.her2-section[data-astro-cid-t7yhajqz] h2[data-astro-cid-t7yhajqz],.biomarker-section[data-astro-cid-t7yhajqz] h2[data-astro-cid-t7yhajqz],.aso-section[data-astro-cid-t7yhajqz] h2[data-astro-cid-t7yhajqz],.references-section[data-astro-cid-t7yhajqz] h2[data-astro-cid-t7yhajqz],.closing-panel[data-astro-cid-t7yhajqz] h2[data-astro-cid-t7yhajqz]{color:var(--phaeno-rna-900);font-size:clamp(2rem,4vw,3.6rem);font-weight:var(--font-weight-medium);letter-spacing:-.04em;margin:0;line-height:1.02}.section-heading[data-astro-cid-t7yhajqz]>p[data-astro-cid-t7yhajqz]:last-child{max-width:44rem;margin:var(--space-4) 0 0;color:var(--phaeno-neutral-700);font-size:var(--font-size-lg);line-height:1.6}.resolution-path[data-astro-cid-t7yhajqz]{gap:var(--space-4);grid-template-columns:1fr auto 1fr auto 1fr;align-items:center;display:grid}.resolution-card[data-astro-cid-t7yhajqz]{border:1px solid var(--phaeno-green-200);border-radius:var(--radius-xl);background:var(--color-surface);min-height:17rem;padding:clamp(1.4rem,2.5vw,2rem)}.resolution-card__label[data-astro-cid-t7yhajqz]{color:var(--color-brand-strong);font-size:var(--font-size-xs);font-weight:var(--font-weight-semibold);letter-spacing:.14em;text-transform:uppercase;margin:0 0 .5rem}.resolution-card[data-astro-cid-t7yhajqz] h3[data-astro-cid-t7yhajqz]{max-width:12ch;margin:0 0 var(--space-4);color:var(--phaeno-rna-900);font-size:clamp(1.45rem,2.3vw,2rem);line-height:1.05}.resolution-card[data-astro-cid-t7yhajqz] p[data-astro-cid-t7yhajqz]:last-child{color:var(--phaeno-neutral-700);margin:0;line-height:1.55}.resolution-card--emphasis[data-astro-cid-t7yhajqz]{border-color:var(--phaeno-rna-800);background:linear-gradient(145deg, var(--phaeno-rna-900), var(--phaeno-rna-800))}.resolution-card--emphasis[data-astro-cid-t7yhajqz] .resolution-card__label[data-astro-cid-t7yhajqz]{color:var(--phaeno-green-300)}.resolution-card--emphasis[data-astro-cid-t7yhajqz] [data-astro-cid-t7yhajqz]:is(h3,p:last-child){color:var(--color-text-on-dark)}.resolution-path__arrow[data-astro-cid-t7yhajqz]{color:var(--color-brand);font-size:1.8rem}.outcome-grid[data-astro-cid-t7yhajqz]{gap:var(--space-4);margin-top:var(--space-4);grid-template-columns:repeat(3,1fr);display:grid}.outcome-grid[data-astro-cid-t7yhajqz] article[data-astro-cid-t7yhajqz]{gap:var(--space-4);padding:var(--space-5);border-radius:var(--radius-xl);background:var(--phaeno-green-100);display:flex}.outcome-grid[data-astro-cid-t7yhajqz] article[data-astro-cid-t7yhajqz]>span[data-astro-cid-t7yhajqz]{height:2.5rem;color:var(--phaeno-rna-800);background:var(--color-surface);border-radius:50%;flex:0 0 2.5rem;place-items:center;display:grid}.outcome-grid[data-astro-cid-t7yhajqz] h3[data-astro-cid-t7yhajqz]{color:var(--phaeno-rna-900);font-size:var(--font-size-lg);margin:0 0 .35rem}.outcome-grid[data-astro-cid-t7yhajqz] p[data-astro-cid-t7yhajqz]{color:var(--phaeno-neutral-700);margin:0;line-height:1.5}.her2-section[data-astro-cid-t7yhajqz]{padding:clamp(3rem,5vw,4.5rem) 0}.her2-section__intro[data-astro-cid-t7yhajqz]{grid-template-columns:minmax(18rem,.85fr) minmax(0,1.15fr);align-items:start;gap:clamp(2rem,8vw,7rem);display:grid}.her2-section__summary[data-astro-cid-t7yhajqz]{padding-top:var(--space-8)}.her2-section__summary[data-astro-cid-t7yhajqz]>p[data-astro-cid-t7yhajqz]{color:var(--phaeno-neutral-700);font-size:var(--font-size-lg);margin:0;line-height:1.65}.evidence-stat[data-astro-cid-t7yhajqz]{gap:var(--space-4);margin-top:var(--space-7);padding-top:var(--space-5);border-top:1px solid var(--phaeno-green-200);align-items:center;display:flex}.evidence-stat[data-astro-cid-t7yhajqz] strong[data-astro-cid-t7yhajqz]{color:var(--color-brand-strong);letter-spacing:-.05em;font-size:clamp(2.3rem,4vw,3.5rem)}.evidence-stat[data-astro-cid-t7yhajqz] span[data-astro-cid-t7yhajqz]{max-width:15rem;color:var(--phaeno-neutral-600);font-size:var(--font-size-sm);line-height:1.4}.quote-grid[data-astro-cid-t7yhajqz]{gap:var(--space-4);grid-template-columns:repeat(2,1fr);margin-top:clamp(2rem,5vw,3.5rem);display:grid}.evidence-quote[data-astro-cid-t7yhajqz]{border:1px solid var(--phaeno-green-200);border-radius:var(--radius-2xl);background:linear-gradient(150deg, var(--color-surface), var(--phaeno-green-50));grid-template-rows:auto 1fr;min-height:0;margin:0;padding:clamp(1.6rem,3vw,2.5rem);display:grid}.evidence-quote[data-astro-cid-t7yhajqz] blockquote[data-astro-cid-t7yhajqz]{max-width:30ch;color:var(--phaeno-rna-900);box-shadow:none;background:0 0;border:0;border-radius:0;margin:0;padding:0;font-size:clamp(1.3rem,2vw,1.75rem);line-height:1.45}.evidence-quote[data-astro-cid-t7yhajqz] figcaption[data-astro-cid-t7yhajqz]{gap:var(--space-4);margin-top:var(--space-5);padding-top:var(--space-5);border-top:1px solid var(--phaeno-green-200);align-self:end;align-items:flex-start;display:flex}.evidence-quote[data-astro-cid-t7yhajqz] img[data-astro-cid-t7yhajqz]{object-fit:cover;filter:grayscale();border-radius:50%;width:3.5rem;height:3.5rem}.evidence-quote[data-astro-cid-t7yhajqz] figcaption[data-astro-cid-t7yhajqz] span[data-astro-cid-t7yhajqz]{min-width:0;color:var(--phaeno-rna-900);flex-direction:column;display:flex}.evidence-quote[data-astro-cid-t7yhajqz] figcaption[data-astro-cid-t7yhajqz] strong[data-astro-cid-t7yhajqz]{color:var(--phaeno-rna-900)}.evidence-quote[data-astro-cid-t7yhajqz] small[data-astro-cid-t7yhajqz]{color:var(--phaeno-neutral-600);margin-top:.3rem;line-height:1.4}.evidence-quote--dark[data-astro-cid-t7yhajqz]{border-color:var(--phaeno-rna-800);background:linear-gradient(145deg, var(--phaeno-rna-900), var(--phaeno-rna-800))}.evidence-quote--dark[data-astro-cid-t7yhajqz] [data-astro-cid-t7yhajqz]:is(blockquote,figcaption span){color:var(--color-text-on-dark)}.evidence-quote--dark[data-astro-cid-t7yhajqz] figcaption[data-astro-cid-t7yhajqz]{border-top-color:#ffffff47}.evidence-quote--dark[data-astro-cid-t7yhajqz] figcaption[data-astro-cid-t7yhajqz] strong[data-astro-cid-t7yhajqz]{color:var(--color-text-on-dark)}.evidence-quote--dark[data-astro-cid-t7yhajqz] small[data-astro-cid-t7yhajqz]{color:var(--phaeno-green-200)}.biomarker-section[data-astro-cid-t7yhajqz]{border-radius:var(--radius-2xl);background:var(--phaeno-green-50);padding:clamp(2.5rem,4.5vw,4.25rem)}.section-heading--split[data-astro-cid-t7yhajqz]{grid-template-columns:1fr minmax(18rem,.65fr);align-items:start;gap:clamp(2rem,6vw,5rem);max-width:none;display:grid}.section-heading--split[data-astro-cid-t7yhajqz] h2[data-astro-cid-t7yhajqz]{padding:0}.section-heading[data-astro-cid-t7yhajqz].section-heading--split>p[data-astro-cid-t7yhajqz]{padding:var(--space-5) 0 0;color:var(--phaeno-neutral-700);font-size:var(--font-size-lg);margin:0 0 .25rem;line-height:1.6}.biomarker-table[data-astro-cid-t7yhajqz]{border:1px solid var(--phaeno-green-200);border-radius:var(--radius-xl);background:var(--color-surface);overflow:hidden}.biomarker-table__header[data-astro-cid-t7yhajqz],.biomarker-row[data-astro-cid-t7yhajqz]{grid-template-columns:.65fr 1.15fr 1fr 1.7fr;display:grid}.biomarker-table__header[data-astro-cid-t7yhajqz]{color:var(--phaeno-green-200);background:var(--phaeno-rna-900);font-size:var(--font-size-xs);font-weight:var(--font-weight-semibold);letter-spacing:.12em;text-transform:uppercase}.biomarker-table__header[data-astro-cid-t7yhajqz] div[data-astro-cid-t7yhajqz],.biomarker-row[data-astro-cid-t7yhajqz]>div[data-astro-cid-t7yhajqz]{padding:1rem 1.15rem}.biomarker-row[data-astro-cid-t7yhajqz]{color:var(--phaeno-neutral-700);font-size:var(--font-size-sm);line-height:1.45}.biomarker-row[data-astro-cid-t7yhajqz]+.biomarker-row[data-astro-cid-t7yhajqz]{border-top:1px solid var(--phaeno-neutral-200)}.biomarker-row[data-astro-cid-t7yhajqz]:nth-child(odd){background:var(--phaeno-neutral-50)}.biomarker-name[data-astro-cid-t7yhajqz]{color:var(--phaeno-rna-900);font-size:var(--font-size-base);font-weight:var(--font-weight-semibold)}.mobile-label[data-astro-cid-t7yhajqz]{display:none}.aso-section[data-astro-cid-t7yhajqz]{background:var(--phaeno-rna-900);width:100cqw;max-width:none;margin:clamp(3rem,5vw,4.5rem) calc(50% - 50cqw);padding:0}.aso-section__inner[data-astro-cid-t7yhajqz]{width:100%;max-width:var(--content-max-width);padding:clamp(3rem, 6vw, 5rem) var(--page-gutter);margin:0 auto}.aso-section[data-astro-cid-t7yhajqz] .eyebrow[data-astro-cid-t7yhajqz]{color:var(--phaeno-green-300)}.aso-section__body[data-astro-cid-t7yhajqz]{grid-template-columns:1fr .8fr;align-items:center;gap:clamp(2rem,7vw,6rem);display:grid}.aso-section[data-astro-cid-t7yhajqz] h2[data-astro-cid-t7yhajqz]{color:var(--color-text-on-dark)}.aso-section__content[data-astro-cid-t7yhajqz]>p[data-astro-cid-t7yhajqz]:not(.eyebrow){color:var(--phaeno-neutral-200);font-size:var(--font-size-lg);line-height:1.65}.aso-examples[data-astro-cid-t7yhajqz]{gap:var(--space-4);align-content:center;display:grid}.aso-examples[data-astro-cid-t7yhajqz] article[data-astro-cid-t7yhajqz]{gap:var(--space-4);padding:var(--space-5);border-radius:var(--radius-xl);background:#ffffff12;border:1px solid #ffffff24;display:flex}.aso-examples[data-astro-cid-t7yhajqz] article[data-astro-cid-t7yhajqz] p[data-astro-cid-t7yhajqz]{color:var(--phaeno-neutral-300);font-size:var(--font-size-sm);margin:0;line-height:1.45}.aso-examples[data-astro-cid-t7yhajqz] article[data-astro-cid-t7yhajqz] p[data-astro-cid-t7yhajqz]:first-child{color:var(--phaeno-green-300);font-size:var(--font-size-xs);font-weight:var(--font-weight-semibold);letter-spacing:.1em;text-transform:uppercase}.aso-examples[data-astro-cid-t7yhajqz] h3[data-astro-cid-t7yhajqz]{color:var(--color-text-on-dark);margin:.4rem 0 .55rem;font-size:1.5rem}.references-section[data-astro-cid-t7yhajqz]{grid-template-columns:minmax(15rem,.45fr) minmax(0,1fr);gap:clamp(2rem,7vw,6rem);padding-bottom:clamp(3rem,5vw,4.5rem);display:grid}.references-section__heading[data-astro-cid-t7yhajqz]{align-self:start;position:sticky;top:6rem}.references-section__heading[data-astro-cid-t7yhajqz]>p[data-astro-cid-t7yhajqz]:last-child{color:var(--phaeno-neutral-600);line-height:1.55}.reference-groups[data-astro-cid-t7yhajqz]{border-top:1px solid var(--phaeno-green-200)}.reference-groups[data-astro-cid-t7yhajqz] details[data-astro-cid-t7yhajqz]{border-bottom:1px solid var(--phaeno-green-200)}.reference-groups[data-astro-cid-t7yhajqz] summary[data-astro-cid-t7yhajqz]{color:var(--phaeno-rna-900);font-size:var(--font-size-lg);font-weight:var(--font-weight-semibold);cursor:pointer;justify-content:space-between;padding:1.4rem 0;list-style:none;display:flex}.reference-groups[data-astro-cid-t7yhajqz] summary[data-astro-cid-t7yhajqz]::-webkit-details-marker{display:none}.reference-groups[data-astro-cid-t7yhajqz] summary[data-astro-cid-t7yhajqz] span[data-astro-cid-t7yhajqz]{transition:transform var(--duration-fast) var(--ease-standard)}.reference-groups[data-astro-cid-t7yhajqz] details[data-astro-cid-t7yhajqz][open] summary[data-astro-cid-t7yhajqz] span[data-astro-cid-t7yhajqz]{transform:rotate(45deg)}.reference-list[data-astro-cid-t7yhajqz]{padding:0 0 var(--space-6)}.reference-groups[data-astro-cid-t7yhajqz] details[data-astro-cid-t7yhajqz][open]>.reference-list[data-astro-cid-t7yhajqz]{animation:reference-list-reveal var(--duration-base) var(--ease-standard) both}@keyframes reference-list-reveal{0%{opacity:0;transform:translateY(-.25rem)}to{opacity:1;transform:translateY(0)}}.reference-list[data-astro-cid-t7yhajqz] p[data-astro-cid-t7yhajqz]{color:var(--phaeno-neutral-600);font-size:var(--font-size-sm);line-height:1.55}.reference-list--columns[data-astro-cid-t7yhajqz]{gap:var(--space-5);grid-template-columns:repeat(2,1fr);display:grid}.reference-list--columns[data-astro-cid-t7yhajqz] div[data-astro-cid-t7yhajqz]{padding:var(--space-5);border-radius:var(--radius-lg);background:var(--phaeno-neutral-50)}.reference-list--columns[data-astro-cid-t7yhajqz] p[data-astro-cid-t7yhajqz]:first-child{color:var(--phaeno-rna-900);margin-top:0}.closing-panel[data-astro-cid-t7yhajqz]{background:var(--phaeno-green-100);width:100cqw;max-width:none;margin:0 calc(50% - 50cqw);padding:0}.closing-panel__inner[data-astro-cid-t7yhajqz]{width:100%;max-width:var(--content-max-width);padding:clamp(3rem, 6vw, 5rem) var(--page-gutter);margin:0 auto}.closing-panel__content[data-astro-cid-t7yhajqz]{justify-content:space-between;gap:var(--space-7);align-items:center;display:flex}.closing-panel[data-astro-cid-t7yhajqz] h2[data-astro-cid-t7yhajqz]{max-width:17ch;font-size:clamp(2rem,3.5vw,3.2rem)}.closing-panel__actions[data-astro-cid-t7yhajqz]{gap:var(--space-3);flex-shrink:0;display:flex}.closing-panel[data-astro-cid-t7yhajqz] a[data-astro-cid-t7yhajqz]{border-radius:var(--radius-pill);font-weight:var(--font-weight-semibold);transition:color var(--duration-fast) var(--ease-standard), background-color var(--duration-base) var(--ease-standard), box-shadow var(--duration-base) var(--ease-standard), transform var(--duration-fast) var(--ease-standard);border:1px solid #0000;padding:.9rem 1.35rem}.button-primary[data-astro-cid-t7yhajqz]{color:var(--color-text-on-dark);background:var(--phaeno-orange-500)}.button-primary[data-astro-cid-t7yhajqz]:hover{color:var(--color-text-on-dark);background:var(--phaeno-orange-600);box-shadow:var(--shadow-md);transform:translateY(-1px)}.button-secondary[data-astro-cid-t7yhajqz]{color:var(--phaeno-rna-900);border-color:var(--phaeno-rna-800)!important}.button-secondary[data-astro-cid-t7yhajqz]:hover{color:var(--color-text-on-dark);background:var(--phaeno-rna-900);transform:translateY(-1px)}@media (width<=950px){.intro-section[data-astro-cid-t7yhajqz],.aso-section__body[data-astro-cid-t7yhajqz],.references-section[data-astro-cid-t7yhajqz]{grid-template-columns:1fr}.intro-section[data-astro-cid-t7yhajqz]{align-items:start}.intro-section__copy[data-astro-cid-t7yhajqz]{max-width:48rem;padding-top:0}.quote-grid[data-astro-cid-t7yhajqz]{grid-template-columns:1fr}.outcome-grid[data-astro-cid-t7yhajqz]{grid-template-columns:repeat(2,1fr)}.outcome-grid[data-astro-cid-t7yhajqz] article[data-astro-cid-t7yhajqz]:last-child{grid-column:1/-1}.resolution-path[data-astro-cid-t7yhajqz]{grid-template-columns:1fr}.resolution-path__arrow[data-astro-cid-t7yhajqz]{justify-self:center;transform:rotate(90deg)}.resolution-card[data-astro-cid-t7yhajqz]{min-height:auto}.her2-section__intro[data-astro-cid-t7yhajqz]{grid-template-columns:1fr;align-items:start;max-width:48rem}.her2-section__summary[data-astro-cid-t7yhajqz]{padding-top:0}.references-section__heading[data-astro-cid-t7yhajqz]{position:static}.closing-panel__content[data-astro-cid-t7yhajqz]{flex-direction:column;align-items:flex-start}}@media (width<=725px){.intro-section[data-astro-cid-t7yhajqz]{gap:var(--space-7);padding:2rem 0}.intro-section[data-astro-cid-t7yhajqz] h2[data-astro-cid-t7yhajqz]{font-size:clamp(2.5rem,13vw,4rem)}.resolution-section[data-astro-cid-t7yhajqz],.biomarker-section[data-astro-cid-t7yhajqz]{border-radius:var(--radius-xl);margin-left:-.25rem;margin-right:-.25rem;padding:1.5rem}.outcome-grid[data-astro-cid-t7yhajqz],.quote-grid[data-astro-cid-t7yhajqz],.section-heading--split[data-astro-cid-t7yhajqz],.reference-list--columns[data-astro-cid-t7yhajqz]{grid-template-columns:1fr}.section-heading[data-astro-cid-t7yhajqz].section-heading--split>p[data-astro-cid-t7yhajqz]{padding-top:0}.outcome-grid[data-astro-cid-t7yhajqz] article[data-astro-cid-t7yhajqz]:last-child{grid-column:auto}.evidence-quote[data-astro-cid-t7yhajqz]{min-height:0}.biomarker-table[data-astro-cid-t7yhajqz]{background:0 0;border:0;overflow:visible}.biomarker-table__header[data-astro-cid-t7yhajqz]{display:none}.biomarker-row[data-astro-cid-t7yhajqz]{gap:var(--space-3);margin-bottom:var(--space-4);padding:var(--space-5);border-radius:var(--radius-xl);grid-template-columns:1fr;display:grid;border:1px solid var(--phaeno-green-200)!important;background:var(--color-surface)!important}.biomarker-row[data-astro-cid-t7yhajqz]>div[data-astro-cid-t7yhajqz]{padding:0}.biomarker-name[data-astro-cid-t7yhajqz]{border-bottom:1px solid var(--phaeno-neutral-200);font-size:1.3rem;padding-bottom:var(--space-3)!important}.mobile-label[data-astro-cid-t7yhajqz]{color:var(--color-brand-strong);font-size:.7rem;font-weight:var(--font-weight-semibold);letter-spacing:.1em;text-transform:uppercase;margin-bottom:.2rem;display:block}.aso-section[data-astro-cid-t7yhajqz]{margin-top:3.5rem;margin-bottom:3.5rem}.aso-section__inner[data-astro-cid-t7yhajqz]{padding:2.5rem var(--page-gutter)}.closing-panel__actions[data-astro-cid-t7yhajqz]{flex-direction:column;width:100%}.closing-panel[data-astro-cid-t7yhajqz] a[data-astro-cid-t7yhajqz]{text-align:center;width:100%}}